An ADH 1B Variant and Peer Drinking in Progression to Adolescent Drinking Milestones: Evidence of a Gene‐by‐Environment Interaction
Year: 2014
Type: article
Abstract: BACKGROUND: Adolescent drinking is an important public health concern, one that is influenced by both genetic and environmental factors. The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations. However, few data are available regarding whether this variant influences early drinking behaviors and whether social context moderates this effect. This study examines the interplay between rs1229984 and peer drinking in the development of adolescent drinking milestones. METHODS: One thousand five hundred and fifty European and African American individuals who had a full drink of alcohol before age 18 were selected from a longitudinal study of youth as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Cox proportional hazards regression, with G × E product terms in the final models, was used to study 2 primary outcomes during adolescence: age of first intoxication and age of first DSM-5 alcohol use disorder symptom. RESULTS: The minor A allele of rs1229984 was associated with a protective effect for first intoxication (HR = 0.56, 95% CI 0.41 to 0.76) and first DSM-5 symptom (HR = 0.45, 95% CI 0.26 to 0.77) in the final models. Reporting that most or all best friends drink was associated with a hazardous effect for first intoxication (HR = 1.81, 95% CI 1.62 to 2.01) and first DSM-5 symptom (HR = 2.17, 95% 1.88 to 2.50) in the final models. Furthermore, there was a significant G × E interaction for first intoxication (p = 0.002) and first DSM-5 symptom (p = 0.01). Among individuals reporting none or few best friends drinking, the ADH1B variant had a protective effect for adolescent drinking milestones, but for those reporting most or all best friends drinking, this effect was greatly reduced. CONCLUSIONS: Our results suggest that the risk factor of best friends drinking attenuates the protective effect of a well-established ADH1B variant for 2 adolescent drinking behaviors. These findings illustrate the interplay between genetic and environmental factors in the development of drinking milestones during adolescence.
DOI: 10.1111/acer.12524
Authors: Emily Olfson, Howard J. Edenberg, John Nurnberger, Arpana Agrawal, Kathleen K. Bucholz, Laura A. Almasy, David Chorlian, Danielle M. Dick, Victor M. Hesselbrock, John R. Kramer, Samuel Kuperman, Bernice Porjesz, Marc A. Schuckit, Jay A. Tischfield, Jen‐Chyong Wang, Leah Wetherill, Tatiana M. Foroud, John Rice, Alison Goate, Laura J. Bierut
Institutions: Washington University in St. Louis, Indiana University Indianapolis, Indiana University School of Medicine, Texas Biomedical Research Institute, SUNY Downstate Health Sciences University, Virginia Commonwealth University, Virginia Commonwealth University Medical Center, University of Connecticut, UConn Health, University of Iowa, University of California San Diego, Rutgers, The State University of New Jersey
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1083756078, G2202404319, G2481876672, G2988863959, G304139194, G401270983, AGE AT FIRST DRINK AND ALCOHOLISM: INTERSECTION OF GENES AND ENVIRONMENT, G577570207, Washington University Institute of Clinical and Translational Sciences, National Research Service Award-Medical Scientist, G9000025954
OpenAlex ID: W2148954328