Work

Differentiation of Progressive Versus Regressive Rous Virus-induced Avian Sarcomas According to Tumor and Infiltrating Lymphocyte Fine Structure , ,

Year: 1978

Type: article

Abstract: Electron microscope examination of progressing and regressing Rous virus-induced sarcomas in an inbred line of White Leghorns revealed that regressing tumors contained moderate to marked lymphocyte infiltration, frequent contact between lymphocytes and tumor cells, and extensive areas of necrosis. Lymphocytes infiltrating regressing tumors exhibited a polar accumulation of organelles at the point of contact between lymphocyte and target cell. On the other hand, progressing tumors contained low to moderate numbers of lymphocytes, infrequent lymphocyte-tumor cell interaction and less evidence of tumor cell degeneration. Lymphocytes from progressing tumors lacked the polar organization of organelles. This experimental system is offered as a means of studying the role of lymphocytes in tumor regression.

Source: Poultry Science

DOI: 10.3382/ps.0570080

Authors: L.L. PERRY, T.N. WIGHT, W.M. COLLINS, W.R. DUNLOP

Institution: University of New Hampshire

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,600