Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes
Year: 2007
Type: article
Abstract: The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.
Source: Journal of Virology
DOI: 10.1128/jvi.02509-06
Institutions: Massachusetts General Hospital, Brigham and Women's Hospital, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Harvard University, Lemuel Shattuck Hospital, Centers for Disease Control and Prevention, University of California, San Francisco, Harvard Stem Cell Institute
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Center for AIDS Research, University of Washington, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research
Awards: Impact of post-transplant immunosuppression in HIV infected patients on the host-response to viral co-pathogens, including HCV, CMV, EBV, KSHV, G1722716446, G3341612474, G3348225070, G3551860310, CANCER IN PATIENTS WITH ATAXIA TELANGIECTASIA--REGISTRY, G9000129761, Harvard University Center for AIDS Research
OpenAlex ID: W2149147982