Recruiting Cytotoxic T Cells to Folate‐Receptor‐Positive Cancer Cells
Year: 2013
Type: article
Abstract: A Fab-ulous killer: An anti-CD3 Fab-folate conjugate that targets cytotoxic T cells to folate-receptor-positive (FR+) tumors results in efficient killing of tumor cells by activated T cells. This chemical approach to the synthesis of bispecific antibodies using unnatural amino acids with orthogonal chemical reactivity affords homogenous conjugates with precise control over the relative geometry of the antibody binding sites in excellent yields.
Institutions: Scripps Research Institute, Ambrx (United States)
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G2725281635
OpenAlex ID: W2149269091