Year: 2014
Type: article
Abstract: A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
Source: OncoImmunology
DOI: 10.4161/onci.28500
Authors: Penghui Zhou, Kai W Wucherpfennig
Institutions: Dana-Farber Cancer Institute, Harvard University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,913
Funder: National Cancer Institute
OpenAlex ID: W2149321438