Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/− or Rb1+/− backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signaling
Work
Year: 2010
Type: article
Abstract: PRKAR1A inactivation leads to dysregulated cAMP signaling and Carney complex (CNC) in humans, a syndrome associated with skin, endocrine and other tumors. The CNC phenotype is not easily explained by ... more
Source: Human Molecular Genetics
Authors Madson Q. Almeida, Michael Muchow, Sosipatros A. Boikos, Andrew J. Bauer, Kurt Griffin +8 more
Institutions Eunice Kennedy Shriver National Institute of Child Health and Human Development, Johns Hopkins University, Office of Research Services, National Institutes of Health
Cites: 58
Cited by: 54
Related to: 10
FWCI: 5.181
Citation percentile (by year/subfield): 92.73
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze