Work

Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients

Year: 2002

Type: article

Abstract: PURPOSE: To evaluate the role of 3D MR spectroscopic imaging (MRSI) as a tool for characterizing heterogeneity within a lesion in glioma patients. MATERIALS AND METHODS: Forty-nine patients with newly diagnosed glioma were studied with 3D water-suppressed proton (1-H) MRSI. Signal intensities from choline (Cho), creatine (Cr), N-acytel aspartate (NAA), and lactate/lipid (LL) were estimated from the spectra. Regions of interest (ROIs) corresponding to the metabolic abnormalities were defined and compared with the anatomic lesions. RESULTS: This study showed that the tumor burden measured with either the volumes of the metabolic abnormalities or the metabolic levels in the most abnormal voxels was correlated with the degree of malignancy of the tumor. The volumes of elevated Cho and decreased NAA were useful for distinguishing low-grade from high-grade lesions. The volume of abnormal LL was correlated with the existence of necrosis and with the volume of contrast-enhancing lesions in high-grade lesions. The differences in the volume of abnormal LL were also statistically significant between patients in each grade. CONCLUSION: These 3D-MRSI data provide important additional information to conventional MRI for evaluating and characterizing gliomas.

Source: Journal of Magnetic Resonance Imaging

DOI: 10.1002/jmri.10147

Authors: Xiaojuan Li, Ying Lu, Andrea Pirzkall, Tracy McKnight, Sarah J. Nelson

Institution: University of California, San Francisco

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute