Nutritional Metabolomics: Progress in Addressing Complexity in Diet and Health
Year: 2012
Type: review
Abstract: Nutritional metabolomics is rapidly maturing to use small-molecule chemical profiling to support integration of diet and nutrition in complex biosystems research. These developments are critical to facilitate transition of nutritional sciences from population-based to individual-based criteria for nutritional research, assessment, and management. This review addresses progress in making these approaches manageable for nutrition research. Important concept developments concerning the exposome, predictive health, and complex pathobiology serve to emphasize the central role of diet and nutrition in integrated biosystems models of health and disease. Improved analytic tools and databases for targeted and nontargeted metabolic profiling, along with bioinformatics, pathway mapping, and computational modeling, are now used for nutrition research on diet, metabolism, microbiome, and health associations. These new developments enable metabolome-wide association studies (MWAS) and provide a foundation for nutritional metabolomics, along with genomics, epigenomics, and health phenotyping, to support the integrated models required for personalized diet and nutrition forecasting.
Source: Annual Review of Nutrition
Authors: Dean P. Jones, Youngja Park, Thomas R. Ziegler
Institution: Emory University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: Atlanta Clinical and Translational Science Institute (UL1), Metabolomics of subclinical and clinical cardiovascular disease, Thioredoxin-2 protection against mitochondrial oxidative toxicity, Redox disturbances and corticosteroid responses in children with severe asthma, Efficacy and Mechanisms of GLN Dipeptide in the SICU, Patient Oriented Research in Clinical Nutrition, HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE, Emory Alcohol and Lung Biology Center, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Emory Parkinson's Disease Collaborative Environmental Research Center, A metabolomic model of aging in the common marmoset, Comparative effectiveness of energy dose in critical illness, Nuclear and cytoplasmic redox in oxidative stress
OpenAlex ID: W2149493695