Vaccine-Induced Gag-Specific T Cells Are Associated With Reduced Viremia After HIV-1 Infection
Year: 2013
Type: article
Abstract: The contribution of host T-cell immunity and HLA class I alleles to the control of human immunodeficiency virus (HIV-1) replication in natural infection is widely recognized. We assessed whether vaccine-induced T-cell immunity, or expression of certain HLA alleles, impacted HIV-1 control after infection in the Step MRKAd5/HIV-1 gag/pol/nef study. Vaccine-induced T cells were associated with reduced plasma viremia, with subjects targeting ≥3 gag peptides presenting with half-log lower mean viral loads than subjects without Gag responses. This effect was stronger in participants infected proximal to vaccination and was independent of our observed association of HLA-B*27, -B*57 and -B*58:01 alleles with lower HIV-1 viremia. These findings support the ability of vaccine-induced T-cell responses to influence postinfection outcome and provide a rationale for the generation of T-cell responses by vaccination to reduce viremia if protection from acquisition is not achieved. Clinical trials identifier: NCT00095576.
Institutions: Fred Hutch Cancer Center, Universidade de São Paulo, Center for Infectious Disease Research, Merck & Co., Inc., Rahway, NJ, USA (United States), Ragon Institute of MGH, MIT and Harvard, Frederick National Laboratory for Cancer Research, Massachusetts Institute of Technology, University of Washington
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2149551637