Work

Beneficial Effect of Oral Tigecycline Treatment on Clostridium difficile Infection in Gnotobiotic Piglets

Year: 2014

Type: article

Abstract: The efficacy of oral tigecycline treatment (2 mg/kg of body weight for 7 days) of Clostridium difficile infection (CDI) was evaluated in the gnotobiotic pig model, and its effect on human gut microflora transplanted into the gnotobiotic pig was determined. Tigecycline oral treatment improved survival, clinical signs, and lesion severity and markedly decreased concentrations of Firmicutes but did not promote CDI. Our data showed that oral tigecycline treatment has a potential beneficial effect on the treatment of CDI.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.03447-14

Authors: Hyeun Bum Kim, Quanshun Zhang, Xingmin Sun, Gillian Beamer, Yuankai Wang, Saul Tzipori

Institutions: Tufts University, Dankook University

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases