Work

Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

Year: 2011

Type: article

Study design: Observational Study

Abstract: Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.

Source: Clinical and Vaccine Immunology

DOI: 10.1128/cvi.05107-11

Authors: Roberto Calcedo, Hiroki Morizono, Lili Wang, Robert McCarter, Jianping He, David Jones, Mark L. Batshaw, James M. Wilson

Institutions: University of Pennsylvania, Children's National

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G167242981, Clinical and Translational Science Institute at Children's National, Gene Therapy for Urea Cycle Disorders, G736570329

OpenAlex ID: W2149757665

FWCI: 8.398

Cites: 19

Cited by: 345

Related to: 10