Work

Measurement of intrinsic properties of amyloid fibrils by the peak force QNM method

Year: 2012

Type: article

Abstract: We report the investigation of the mechanical properties of different types of amyloid fibrils by the peak force quantitative nanomechanical (PF-QNM) technique. We demonstrate that this technique correctly measures the Young's modulus independent of the polymorphic state and the cross-sectional structural details of the fibrils, and we show that values for amyloid fibrils assembled from heptapeptides, α-synuclein, Aβ(1-42), insulin, β-lactoglobulin, lysozyme, ovalbumin, Tau protein and bovine serum albumin all fall in the range of 2-4 GPa.

Source: Nanoscale

DOI: 10.1039/c2nr30768e

Authors: Jozef Adamcik, Cecile Lara, Ivan Usov, Jae Sun Jeong, Francesco S. Ruggeri, Giovanni Dietler, Hilal A. Lashuel, Ian W. Hamley, Raffaele Mezzenga

Institutions: ETH Zurich, Institute of Food, Nutrition, and Health, École Polytechnique Fédérale de Lausanne, University of Reading

Language: English

Topic: Force Microscopy Techniques and Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2149948979

FWCI: 7.892

Cites: 34

Cited by: 198

Related to: 9