Work

Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the E mu enhancer.

Year: 2003

Type: article

Abstract: In Burkitt's Lymphoma there is an up-regulation of the c-myc oncogene caused by its translocation from chromosome 8 to chromosome 14, often close to the E mu enhancer of the immunoglobulin heavy chain locus (IgH). In Burkitt's Lymphoma cells, a peptide nucleic acid complementary for a specific unique E mu intronic sequence selectively blocked the expression of the c-myc oncogene under E mu control but not of other c-myc alleles. This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications.

Source: PubMed

Authors: Giovanna Cutrona, Elisabetta M Carpaneto, Anna Ponzanelli, Massimo Ulivi, Enrico Millo, Sonia Scarfì, Silvio Roncella, Umberto Benatti, Lidia C Boffa, Manlio Ferrarini

Institutions: Istituto Superiore di Sanità, TIB Molbiol (Germany), Azienda Ospedaliera Sant'Andrea, Ospedale Policlinico San Martino

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2150079111

FWCI: 1.32

Cites: 20

Cited by: 38

Related to: 10