Work

Mode of action of antimicrobial proteins, pore-forming toxins and biologically active peptides (Hypothesis)

Year: 2005

Type: review

Abstract: Antimicrobial peptides and pore-forming toxins are important effectors in innate immune defencereactions. But their mode of action, comprising the insertion into cholesterol-containing membranes isnot known. Here we explore the mechanical implications of pore-formation by extracellular proteinassemblies that drive cellular uptake reactions by leverage-mediated (LM) processes, whereoligomeric adhesion molecules bent membrane-receptors around ‘hinge’-like lipophorin particles. Theinteractions of antimicrobial peptides, pore-forming toxins and biologically active proteins with LMassembliesprovide a new paradigm for the configurational specificity and sterical selectivity ofbiologically active peptides.

Source: Invertebrate survival journal

Authors: O. Schmidt, Md. Mahbubur Rahman, Gang Ma, Ulrich Theopold, Yue Sun, Muhammad Sarjan, Marco Fabbri, Harry Roberts

Institutions: The University of Adelaide, Stockholm University, Shanxi Academy of Agricultural Sciences, University of Mataram, European Institute of Oncology

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W2150084690

FWCI: 0.12

Cites: 49

Cited by: 7

Related to: 10