Central auditory maturation and behavioral outcome in children with auditory neuropathy spectrum disorder who use cochlear implants
Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We examined cortical auditory development and behavioral outcomes in children with ANSD fitted with cochlear implants (CI). DESIGN: Cortical maturation, measured by P1 cortical auditory evoked potential (CAEP) latency, was regressed against scores on the infant toddler meaningful auditory integration scale (IT-MAIS). Implantation age was also considered in relation to CAEP findings. STUDY SAMPLE: Cross-sectional and longitudinal samples of 24 and 11 children, respectively, with ANSD fitted with CIs. RESULTS: P1 CAEP responses were present in all children after implantation, though previous findings suggest that only 50-75% of ANSD children with hearing aids show CAEP responses. P1 CAEP latency was significantly correlated with participants' IT-MAIS scores. Furthermore, more children implanted before age two years showed normal P1 latencies, while those implanted later mainly showed delayed latencies. Longitudinal analysis revealed that most children showed normal or improved cortical maturation after implantation. CONCLUSION: Cochlear implantation resulted in measureable cortical auditory development for all children with ANSD. Children fitted with CIs under age two years were more likely to show age-appropriate CAEP responses within six months after implantation, suggesting a possible sensitive period for cortical auditory development in ANSD. That CAEP responses were correlated with behavioral outcome highlights their clinical decision-making utility.
Authors: Garrett Cardon, Anu Sharma
Institutions: University of Colorado Boulder, University of Colorado System
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2150095540