Work

Distinct Human Immunodeficiency Virus Strains in the Bone Marrow Are Associated with the Development of Thrombocytopenia

Year: 1999

Type: article

Abstract: We analyzed bone marrow and blood from human immunodeficiency virus type 1 (HIV-1)-infected individuals and described the HIV-1 quasispecies in these cellular compartments. HIV-1 isolates from the bone marrow of thrombocytopenic patients contained distinct amino acids in the V3 loop and infected T-cell lines, implicating this virus in the development of thrombocytopenia.

Source: Journal of Virology

DOI: 10.1128/jvi.73.4.3497-3504.1999

Authors: Frosso Voulgaropoulou, Benjamin Tan, Marcelo Soares, Beatrice Hahn, Lee Ratner

Institutions: University of Alabama, University of Alabama at Birmingham, Washington University in St. Louis

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases