Prevalence of hypercholesterolemia in hypothyroidism compared with euthyroid controls: effects of levothyroxin replacement therapy.
Year: 2010
Type: article
Abstract: Background: Hypothyroidism (HT), a relatively common condition among general population is associated with lipid profile abnormalities. The present study was designed to determine the contributive role of HT in the development of hypercholesterolemia (HCH). Methods: One hundred thirty six consecutive patients with HT and 272 euthyroid controls entered the study. Serum total cholesterol (CH) level was determined before and after treatment of HT and compared with controls. Frequency of subjects with HCH defined as plasma total CH level >240 mg/dl, were determined and compared between hypothyroid patients and sex - age-matched controls. The contributive role of HT in the development of HCH was determined by the comparison of pretreatment and post-treatment CH levels. HT-induced HCH was regarded as restoration of HCh (reduction of CH level to less than 240 (mg/d) after achievement of euthyroid state with thyroid hormone. Results: The mean ages of patients and controls were 43±13 and 44±13 years, respectively. In HT patients the frequency of HCH and mean level of Ch were significantly higher compared with sex and age-matched euthyroid controls. Replacement therapy of 44 HT patients resulted to a significant reduction of CH level from baseline by 22% (p 240mg/dl. Conclusion: The results show contributive role for HT in the development of HCH. Two different
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2150315258