Work

B Cells Regulate CD4+ T Cell Responses to Papain following B Cell Receptor–Independent Papain Uptake

Year: 2014

Type: article

Abstract: Papain, a cysteine protease allergen with inherent adjuvant activity, induces potent IL-4 expression by T cells in the popliteal lymph nodes of mice following footpad immunization. In this study, we identify a novel, non-BCR-mediated capacity for B cells to rapidly bind and internalize papain. B cells subsequently regulate the adaptive immune response by enhancing ICOS expression on CD4(+) T cells and amplifying Th2 and follicular helper T cell induction. Ab blockade of ICOS ligand, expressed by popliteal lymph node B cells, but not dendritic cells, at the peak of the response inhibits IL-4 responses in wild-type mice but not B cell-deficient mice. Thus, B cells play a critical role in amplifying adjuvant-dependent Th2 polarization following noncanonical acquisition and internalization of the cysteine protease papain.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.1303247

Authors: Daniel F Dwyer, Matthew C Woodruff, Michael C Carroll, K Frank Austen, Michael F Gurish

Institutions: Brigham and Women's Hospital, Harvard University, Boston Children's Hospital

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases