Work

Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation

Year: 2008

Type: review

Abstract: Actions of chemokines and the interaction with specific receptors go beyond their original, defined role of recruiting leukocytes to inflamed tissues. Chemokine receptor expression in peripheral elements and resident cells of the central nervous system (CNS) represents a relevant communication system during neuroinflammatory conditions. The following examples are described in this review: Chemokine receptors play important homeostatic properties by regulating levels of specific ligands in blood and tissues during healthy and pathological conditions; chemokines and their receptors are clearly involved in leukocyte extravasation and recruitment to the CNS, and current studies are directed toward understanding the interaction between chemokine receptors and matrix metalloproteinases in the process of blood brain barrier breakdown. We also propose novel functions of chemokine receptors during demyelination/remyelination, and developmental processes.

Source: Journal of Leukocyte Biology

DOI: 10.1189/jlb.1107763

Authors: Astrid E Cardona, Meizhang Li, Liping Liu, Carine Savarin, Richard M Ransohoff

Institutions: Cleveland Clinic, Cleveland Clinic Research

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Multiple Sclerosis Society, National Institutes of Health, National Institute of Neurological Disorders and Stroke