Work

Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

Year: 2014

Type: article

Study design: Observational Study

Abstract: Alzheimer's disease (AD) and non-pathological cognitive aging have phenotypic similarities which may be influenced by an overlapping set of genetic variants. Genome-wide complex trait analysis estimates that common genetic variants account for about 24% of the variation contributing to liability for AD. It is also estimated that 24% of the variance of non-pathological cognitive aging is accounted for by common single nucleotide polymorphisms. However, although the APOE locus is associated with both AD and cognitive aging, it is not known to what extent other common genetic variants, with smaller effect sizes that influence both, overlap. We test the hypothesis that polygenic risk for AD is associated with cognitive ability and cognitive change in about 3,000 non-demented older people (Cognitive Ageing Genetics England and Scotland-CAGES-consortium). We found no significant association of polygenic risk for AD with cognitive ability or cognitive change in CAGES, indicating that the genetic etiologies of AD and non-pathological cognitive decline differ.

Source: Journal of Alzheimer s Disease

DOI: 10.3233/jad-131058

Authors: Sarah E. Harris, Gail Davies, Michelle Luciano, Antony Payton, Helen C. Fox, Paul Haggarty, William Ollier, Michael Horan, David J. Porteous, John M. Starr, Lawrence J. Whalley, Neil Pendleton, Ian J. Deary

Institutions: Western General Hospital, Institute of Genetics and Cancer, University of Edinburgh, University of Manchester, University of Aberdeen, Salford Royal NHS Foundation Trust, Alzheimer Scotland, Cardiff University, Medical Research Council

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Juvenile Diabetes Research Foundation International, Wellcome Trust, Alzheimer's Research Trust, National Institute for Health and Care Research, Royal Society, University of Edinburgh, Bundesministerium für Bildung und Forschung, Alfried Krupp von Bohlen und Halbach-Stiftung, University College London Hospitals NHS Foundation Trust, H. Lundbeck A/S, Centre for Cognitive Ageing and Cognitive Epidemiology, Heinz Nixdorf Stiftung, National Institutes of Health, Directorate for Biological Sciences, Medical Research Council, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, Helmholtz Zentrum München, National Institute on Aging, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development

Awards: G1093300281, G2203296282, G4641403149, A genome-wide association study of non-pathological cognitive ageing, G5067462658, A genome-wide association study of non-pathological cognitive ageing

OpenAlex ID: W2150823966

FWCI: 3.813

Cites: 34

Cited by: 50

Related to: 10