Work

Differential Requirements for T Cells in Viruslike Particle- and Rotavirus-Induced Protective Immunity

Year: 2008

Type: article

Abstract: Correlates of protection from rotavirus infection are controversial. We compared the roles of B and T lymphocytes in protective immunity induced either by intranasally administered nonreplicating viruslike particles or inactivated virus or by orally administered murine rotavirus. We found that protection induced by nonreplicating vaccines requires CD4(+) T cells and CD40/CD40L. In contrast, T cells were not required for short-term protective immunity induced by infection, but both T-cell-dependent and -independent mechanisms contributed to long-term maintenance of protection. Our findings indicate that more than one marker of protective immunity exists and that these markers depend on the vaccine that is administered.

Source: Journal of Virology

DOI: 10.1128/jvi.01727-07

Authors: Sarah E. Blutt, Kelly L. Warfield, Mary K. Estes, Margaret E. Conner

Institutions: Michael E. DeBakey VA Medical Center, Baylor College of Medicine

Language: English

Topic: Viral gastroenteritis research and epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green