Therapeutic Potential of Lung Epithelial Progenitor Cells Derived from Embryonic and Induced Pluripotent Stem Cells
Year: 2010
Type: review
Abstract: Embryonic stem (ES) cells derived from preimplantation blastocysts and induced pluripotent stem (iPS) cells generated from somatic cell sources are pluripotent and capable of indefinite expansion in vitro. They provide a possible unlimited source of cells that could be differentiated into lung progenitor cells for potential clinical use in pulmonary regenerative medicine. Because of inherent difficulties in deriving endodermal cells from undifferentiated cell cultures, applications using lung epithelial cells derived from ES and iPS cells have lagged behind similar efforts devoted to other tissues, such as the heart and spinal cord. However, during the past several years, significant advances in culture, differentiation, and purification protocols, as well as in bioengineering methodologies, have fueled enthusiasm for the development of stem cell-based lung therapeutics. This article provides an overview of recent research achievements and discusses future technical challenges that must be met before the promise of stem cell applications for lung disease can be realized.
Source: Annual Review of Medicine
Authors: Rick A. Wetsel, Dachun Wang, Daniel G. Calame
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Center for Clinical and Translational Sciences (CCTS), Center for Clinical and Translational Sciences, G580208524, Gene corrected iPS-derived lung cells for therapy of inherited lung diseases, Engineering three dimensional tissues using electrochemistry, G7134382721, G7970543966, G8694438205
OpenAlex ID: W2151063935