Work

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

Year: 2013

Type: review

Abstract: This review provides a literature overview of bioorthogonal ligation methods for protein modification, which have largely evolved over the last 15 years. Since 1990, various new reactions have been developed that do not involve naturally occurring functional handles. Especially the development of such so-called bioorthogonal ligations has significantly contributed to our ability to selectively modify biomolecules not only in the test tube, but also in living systems.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c3ob41329b

Authors: Marjoke F. Debets, Jan C. M. van Hest, Floris P. J. T. Rutjes

Institution: Radboud University Nijmegen

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Award: Functional polymersomes: from artificial organelles to cascade reactors