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How to Explain Multidrug Resistance in Epilepsy?

Year: 2005

Type: article

Abstract: Despite advancements in antiepileptic therapy, about one third of people with epilepsy will remain intractable to medication. The initial response to antiepileptic drug therapy is highly predictive of long-term outcome. However, the mechanisms of medical intractability of epilepsy are only incompletely understood. Current interest is focused on two hypotheses: overexpression of drug efflux transporters and alterations in drug targets in the brain, with the most relevant causative mechanism(s) still to be elucidated.

Source: Epiliepsy currents/Epilepsy currents

DOI: 10.1111/j.1535-7511.2005.05311.x

Author: Wolfgang Löscher

Institution: University of Veterinary Medicine Hannover, Foundation

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institute of Neurological Disorders and Stroke