Association of Bone Activity, Calcium Load, Aortic Stiffness, and Calcifications in ESRD
Year: 2008
Type: article
Study design: Observational Study
Abstract: An inverse relationship between arterial calcifications and bone activity has been documented in patients with ESRD. Calcium overload is associated with arterial calcification, which is associated with arterial stiffening. Whether bone activity interacts with calcium load, aortic stiffness, or arterial calcification is unknown. This study assessed the impact of bone activity on the relationships between the dosage of calcium-containing phosphate binders and aortic stiffness (measured by pulse wave velocity) or abdominal aorta calcification score. Aortic stiffness and calcification were both positively associated with calcium load and negatively associated with bone activity. A significant interaction was found between dosage of calcium-containing phosphate binders and bone activity such that calcium load had a significantly greater influence on aortic calcifications and stiffening in the presence of adynamic bone disease. Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls.
Authors: Ge[Combining Acute Accent]rard M. London, Sylvain J. Marchais, Alain P. Gue[Combining Acute Accent]rin, Pierre Boutouyrie, Fabien Me[Combining Acute Accent]tivier, Marie-Christine de Vernejoul
Institution: Centre Hospitalier Frèderic-Henri Manhès
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2151434420