Work

Molecular mechanisms of glutamate receptor clustering at excitatory synapses

Year: 1998

Type: review

Abstract: The targeting of AMPA- and NMDA-type glutamate receptors to synapses in the central nervous system is essential for efficient excitatory synaptic transmission. Recent studies have indicated that protein-protein interactions of these receptors with synaptic proteins that contain PDZ domains are crucial for receptor targeting. NMDA receptors have been found to bind to the PSD-95 family of proteins, whereas AMPA receptors interact with the PDZ-domain-containing protein GRIP (glutamate receptor interacting protein). PSD-95 and GRIP contain multiple PDZ domains as well as other protein-protein interaction motifs that help to form large macromolecular complexes that may be important for the formation and plasticity of synapses.

Source: Current Opinion in Neurobiology

DOI: 10.1016/s0959-4388(98)80062-7

Authors: Richard J O'Brien, Lit-Fui Lau, Richard L Huganir

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,320

OpenAlex ID: W2151444391

FWCI: 2.748

Cites: 59

Cited by: 273

Related to: 10