Work

Panton‐Valentine Leukocidin Is Not a Virulence Determinant in Murine Models of Community‐Associated Methicillin‐ResistantStaphylococcus aureusDisease

Year: 2008

Type: article

Abstract: Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.

Source: The Journal of Infectious Diseases

DOI: 10.1086/592053

Authors: Juliane Bubeck Wardenburg, Amy M. Palazzolo‐Ballance, Michael Otto, Olaf Schneewind, Frank R. DeLeo

Institutions: University of Chicago, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development