Role of Th17 cells in health and disease
Year: 2011
Type: dissertation
Abstract: Th17 cells are a recently discovered novel subset of helper T cells. Th17 cells\ndifferentiate along a different lineage than Th1 and Th2 cells. Already many factors\nwhich play an important role in the differentiation of Th17 cells have been discovered,\nlike IL-6, TGF-β, IL-21, and IL-23. Also intracellular factors, like STAT3, RORγt, and\nRORα, were found. Th17 cells express IL-17 and IL-22, among other cytokines.\nThere is also increasing evidence on the function of these cells within the immune\nsystem. Th17 cells are mostly involved in the chemotaxis of neutrophils and the\nclearance of extracellular bacteria en fungi. Furthermore, Th17 cells have also been\nidentified to play an important role in a broad spectrum of diseases. For instance,\nseveral autoimmune and allergic disorders have been related to Th17 cells, as well\nas other diseases, like inflammatory bowel disease and several forms of cancer. This\nmaster thesis gives an overview of the data discovered on the regulation, function,\nand relation to diseases of Th17 cells.
Author: C.J.C. Coppens
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2151585865