The central nervous system is a target of acute graft versus host disease in mice
Year: 2013
Type: article
Abstract: Despite significant advances in prevention and management, graft versus host disease (GVHD) is still a leading complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although skin, gut, liver, thymus, and lung are GVHD targets, neurological complications (NC) have also been reported following allo-HSCT. We demonstrate that the central nervous system (CNS) can be a direct target of alloreactive T cells following allo-HSCT in mice. We found significant infiltration of the CNS with donor T lymphocytes and cell death of neurons and neuroglia in allo-HSCT recipients with GVHD. We also found that allo-HSCT recipients with GVHD had deficits in spatial learning/memory and demonstrated increased anxious behavior. These findings highlight CNS sensitivity to damage caused by alloreactive donor T cells and represent the first characterization of target cell subsets and NC during GVHD. Therefore, these clinically relevant studies offer a novel and rational explanation for the well-described neurological symptoms observed after allo-HSCT.
Source: Blood
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Neurobiology of anxiety in mice lacking 5HT 1A receptor, Strategies to Enhance Lymphoid Recovery After Radiation-Induced Injury, Non-Genetic Transmission of Genetic Risk: Mechanism and Relevance to Psychiatric, Strategies to enhance immune reconstitution after bone marrow transplant, CEACAM-1a regulates graft-versus-host-disease after allogeneic HSCT, T cell homing in intestinal graft-versus-host disease, Clinical and Translational Science Center, Cancer Center Support Grant
OpenAlex ID: W2151609456