Work

Plasmacytoid Dendritic Cells and Immunotherapy in Multiple Sclerosis

Year: 2012

Type: review

Abstract: Plasmacytoid dendritic cells (pDCs) are specialized APCs implicated in the pathogenesis of many human diseases. Compared with other peripheral blood mononuclear cells, pDCs express a high level of TLR9, which recognizes viral DNA at the initial phase of viral infection. Upon stimulation, these cells produce large amounts of type I interferon and other proinflammatory cytokines and are able to prime T lymphocytes. Thus, pDCs regulate innate and adaptive immune responses. This article reviews select aspects of pDC biology relevant to the disease pathogenesis and immunotherapy in multiple sclerosis. Many unresolved questions remain in this area, promising important future discoveries in pDC research.

Source: Immunotherapy

DOI: 10.2217/imt.12.117

Authors: Felipe von Glehn, Leonilda M Santos, Konstantin E Balashov

Institutions: Universidade Estadual de Campinas (UNICAMP), Rutgers, The State University of New Jersey

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke