Work

Mycobacterium ulceransCytotoxicity in an Adipose Cell Model

Year: 2001

Type: article

Abstract: An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis.

Source: Infection and Immunity

DOI: 10.1128/iai.69.11.7182-7186.2001

Authors: Karen M. Dobos, Pamela L. Small, Manon Deslauriers, Fredrick D. Quinn, C. Harold King

Institutions: Emory University, University of Tennessee at Knoxville, Centers for Disease Control and Prevention, National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention, National Center for Infectious Diseases

Language: English

Topic: Mycobacterium research and diagnosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Health and Human Services, Emory University, Centers for Disease Control and Prevention