Work

High-density lipoprotein is a nanoparticle, but not all nanoparticles are high-density lipoprotein

Year: 2013

Type: article

Abstract: High-density lipoprotein (HDL) is a natural nanoparticle that transports cholesterol from peripheral tissues to the liver and also transports other lipids, proteins, enzymes, and microRNAs. HDL–cholesterol levels are negatively correlated with the risk of cardiovascular events. HDL has also been shown to reduce inflammation and to improve endothelial function (1). Because of HDL’s biological importance, its inherent “stealthy” nature and targeting of certain cell types of interest, several groups, including ours, have developed approaches to label HDL with contrast-generating substances or loaded it with drugs, forming “HDL-like” nanoparticles (2).

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1310107110

Authors: David P. Cormode, Edward A. Fisher, Erik S. G. Stroes, Willem J. M. Mulder, Zahi A. Fayad

Institutions: University of Pennsylvania, New York University, Amsterdam UMC Location University of Amsterdam, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Award: G8807303853