New advances in MR‐compatible bioartificial liver
Year: 2011
Type: review
Abstract: MR-compatible bioartificial liver (BAL) studies have been performed for 30 years and are reviewed. There are two types of study: (i) metabolism and drug studies using multinuclear MRS; primarily short-term (< 8 h) studies; (ii) the use of multinuclear MRS and MRI to noninvasively define the features and functions of BAL systems for long-term liver tissue engineering. In the latter, these systems often undergo not only modification of the perfusion system, but also the construction of MR radiofrequency probes around the bioreactor. We present novel MR-compatible BALs and the use of multinuclear MRS ((13)C, (19)F, (31)P) for the noninvasive monitoring of their growth, metabolism and viability, as well as (1)H MRI methods for the determination of flow profiles, diffusion, cell distribution, quality assurance and bioreactor integrity. Finally, a simple flexible coil design and circuit, and life support system, are described that can make almost any BAL MR-compatible.
Source: NMR in Biomedicine
DOI: 10.1002/nbm.1633
Authors: Rex E. Jeffries, Jeffrey M. Macdonald
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1240654317, G1509035513, G3084420026, G3889484638, Anti-inflammatory Effects of Novel Minor Cannabinoids and Terpenes on Cellular and Murine Models of HIV and HIV Proteins, Integrated Center for InVivo Microscopy, BIOARTIFICIAL LIVERS FROM HEPATIC PROGENITOR CELLS, G6437582980, G7313278231, NMR ANALYSIS OF BIOARTIFICAL LIVER FROM PROGENITORS, G8114260575, Human Enterohepatic Cell Model for Predictive Toxicology, FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
OpenAlex ID: W2151810734