Work

Retinoid X receptors are essential for early mouse development and placentogenesis

Year: 1999

Type: article

Abstract: Embryos carrying null mutations of both retinoid X receptors alpha and beta (RXRalpha-/-/RXRbeta-/- mutants) were generated. These mutant embryos die between 9.5 and 10.5 days of gestation and display a wide range of abnormalities. The cause of the lethality appears to be the lack of formation of the labyrinthine zone of the chorioallantoic placenta. In a thorough analysis of mutant conceptuses, we establish that RXRs, through heterodimerization with retinoic acid receptors, are essential for postimplantation embryonic development before placentogenesis. RXRs are also essential for the formation of the chorioallantoic placenta, most probably through RXR/peroxisomal proliferator-activated receptor-gamma heterodimers. Interestingly, as a RXR ligand appears dispensable, placentogenesis must be controlled by a yet unknown hormonal ligand(s) activating the heterodimerization partner(s) of RXRs.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.96.2.547

Authors: Olivia Wendling, Pierre Chambon, Manuel Mark

Institutions: Centre National de la Recherche Scientifique, Inserm, Collège de France, Institut de génétique et de biologie moléculaire et cellulaire

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2151901281

FWCI: 5.363

Cites: 32

Cited by: 187

Related to: 9