Work

The Metabolically Benign and Malignant Fatty Liver

Year: 2011

Type: article

Abstract: The epidemics of the major metabolic diseasestype 2 diabetes and cardiovascular disease areincreasing worldwide and much effort is beingundertaken to understand the pathogenesis of these conditions. Both type 2 diabetes and cardiovascular disease share insulin resistance as a common and impor-tant risk factor in their natural history. It is now widely accepted that organ cross talk harbors many critical clues that help to better understand the pathogenesis of insulin resistance. In this respect, several studies recently showed that not the increase in body fat mass per se, but the ac-cumulation of fat in the visceral cavity and particularly in the liver, which are conditions commonly accompanied by inflammatory processes, are responsible for the genesis of insulin resistance (1–4). NONALCOHOLIC FATTY LIVER DISEASE Prevalence, pathogenesis, and progression. The prev-alence of nonalcoholic fatty liver disease (NAFLD) has in-

Source: Diabetes

DOI: 10.2337/db11-0231

Authors: Norbert Stefan, Hans-Ulrich Häring

Institution: University of Tübingen

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Deutsche Forschungsgemeinschaft