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B7DC/PDL2 Promotes Tumor Immunity by a PD-1–independent Mechanism

Year: 2003
Type: article
Abstract: B7H1 (PDL1) and B7DC (PDL2) are two new members of the B7 family that can interact with PD-1, a putative negative regulator for immune function. Recent studies have provided evidence for inhibitory functions of both members via PD-1. Meanwhile, compelling evidence exists for costimulatory function of both members. Here we demonstrate that expression of B7DC on the tumor cells promotes CD8 T cell-mediated rejection of tumor cells, at both the induction and effector phase of antitumor immunity. Moreover, B7DC binds to PD-1(-/-) cells and enhances T cell killing in a PD-1-independent mechanism. Our results demonstrate a novel pathway for B7DC to promote tumor immunity and may reconcile the apparently contradictory findings on the function of B7DC.
DOI: 10.1084/jem.20022089
Authors: Xingluo Liu, Jian Xin Gao, Jing Wen, Lijie Yin, Ou Li, Tao Zuo, Thomas F. Gajewski, Yang-Xin Fu, Pan Zheng, Yang Liu
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: bronze
Awards: G1105447502, G1524439704, G223568088, B7 RECEPTORS, TUMOR IMMUNOTHERAPY AND IMMUNE REGULATION, PROTO ONCOGENE PML AND TUMOR EVASION OF HOST IMMUNITY, G3672930693, G4708969133, G6303989892, G855121831, COSTIMULATION FOR MEMORY AND EFFECTOR T CELLS
OpenAlex ID: W2151913741
FWCI: 6.228
Cites: 36
Cited by: 147
Related to: 10