Work

Towards improved animal models of neonatal white matter injury associated with cerebral palsy

Year: 2010

Type: article

Abstract: Newborn neurological injuries are the leading cause of intellectual and motor disabilities that are associated with cerebral palsy. Cerebral white matter injury is a common feature in hypoxic-ischemic encephalopathy (HIE), which affects full-term infants, and in periventricular leukomalacia (PVL), which affects preterm infants. This article discusses recent efforts to model neonatal white matter injury using mammalian systems. We emphasize that a comprehensive understanding of oligodendrocyte development and physiology is crucial for obtaining new insights into the pathobiology of HIE and PVL as well as for the generation of more sophisticated and faithful animal models.

Source: Disease Models & Mechanisms

DOI: 10.1242/dmm.002915

Authors: John C. Silbereis, Eric J. Huang, Stephen A. Back, David H. Rowitch

Institutions: Howard Hughes Medical Institute, University of California, San Francisco, Oregon Health & Science University

Language: English

Topic: Neonatal and fetal brain pathology

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Howard Hughes Medical Institute