Blue Journal Conference. Aging and Susceptibility to Lung Disease
Year: 2015
Type: review
Abstract: The aging of the population in the United States and throughout the developed world has increased morbidity and mortality attributable to lung disease, while the morbidity and mortality from other prevalent diseases has declined or remained stable. Recognizing the importance of aging in the development of lung disease, the American Thoracic Society (ATS) highlighted this topic as a core theme for the 2014 annual meeting. The relationship between aging and lung disease was discussed in several oral symposiums and poster sessions at the annual ATS meeting. In this article, we used the input gathered at the conference to develop a broad framework and perspective to stimulate basic, clinical, and translational research to understand how the aging process contributes to the onset and/or progression of lung diseases. A consistent theme that emerged from the conference was the need to apply novel, systems-based approaches to integrate a growing body of genomic, epigenomic, transcriptomic, and proteomic data and elucidate the relationship between biologic hallmarks of aging, altered lung function, and increased susceptibility to lung diseases in the older population. The challenge remains to causally link the molecular and cellular changes of aging with age-related changes in lung physiology and disease susceptibility. The purpose of this review is to stimulate further research to identify new strategies to prevent or treat age-related lung disease.
Institutions: University of Alabama at Birmingham, National Institutes of Health, National Institute on Aging, Scripps Research Institute, Northwestern University, Helmholtz Munich, Ludwig-Maximilians-Universität München, Instituto Nacional de Enfermedades Respiratorias, Universidad Nacional Autónoma de México, University of Michigan, Brigham and Women's Hospital, Harvard University, Icahn School of Medicine at Mount Sinai, University of Colorado Anschutz, University of Colorado Denver
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, Brigham and Women's Hospital, Yale University, Emory University, University of Minnesota, Cleveland Clinic, University of Washington, Johns Hopkins University, University of Pittsburgh, University of Louisville, University of Oklahoma, University of Rochester, University of South Carolina, National Jewish Health, Rijksuniversiteit Groningen, Universitat de Barcelona, National Institutes of Health, University of California, Los Angeles, Medical Center, University of Pittsburgh, University of North Carolina at Chapel Hill, University of Texas Health Science Center at San Antonio, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences
OpenAlex ID: W2152174546