Work

Bromodomain Blockade for Intimal Hyperplasia — A Good BET?

Year: 2015

Type: article

Abstract: Atherosclerosis contributes to heart attack, stroke, and peripheral vascular disease and remains the leading cause of death in the U.S. (Tabas et al., 2015). Atherosclerotic plaques can be treated by revascularization procedures, including angioplasty, stenting, or bypass surgery, but microtrauma to the blood vessel during these procedures can lead to a complication called intimal hyperplasia, a hyper-proliferation of cells in the vascular lumen (Katz et al., 2015). Smooth muscle cells (SMC), which comprise the muscular layer of arteries, retain the remarkable ability to dedifferentiate in response to injury and assume a repair phenotype.

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2015.11.007

Authors: Allison C. Ostriker, Kathleen A. Martin

Institution: Yale University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780