Effect of mannan and alginate oligosaccharides on production in bioreactors of penicillin G and its biosynthetic intermediates
Year: 2001
Type: article
Abstract: The addition of alginate and mannan oligosaccharides to Penicillium chrysogenum was examined to determine their effects on the production of penicillin G and biosynthetic intermediates.Addition of oligosaccharides to cultures changed the accumulation pattern of the secreted intermediates of penicillin biosynthesis, δ-(L-α-aminoadipyl)-L-cysteinyl-α-D-valine (ACV) and isopenicillin N (IPN) when compared to the control cultures.The culture age at which the oligosaccharides affect penicillin G biosynthesis was determined.After addition of mannan oligosaccharides at 24 hours, the maximum increase in specific productivity of penicillin G compared to the control culture was 130% measured between 96 and 120 hours.
Institution: University of Westminster
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2152278006