Work

Hapten-specific Stimulation of Secondary B Cells Independent of T Cells

Year: 1973

Type: article

Abstract: Treatment of spleen cell suspensions from immunized mice with anti-theta serum and complement before transfer to nonimmune irradiated recipients reduced the degree of in vitro stimulation by hapten-homologous carrier complexes by 90%, but did not decrease at all the number of isolated precursor cells stimulated by hapten on heterologous carriers. Thus, secondary B cells can be stimulated by low concentrations of multiply substituted hapten-carrier complexes in the apparent complete absence of specific T cells.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.138.2.473

Authors: Norman R. Klinman, Robert A. Doughty

Institution: University of Pennsylvania

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Public Health Service, National Institute of Allergy and Infectious Diseases