Year: 2012
Type: article
Abstract: Phosphatidylinositol 4,5 -bisphosphate (PI (4,5) P2) is not only a component of the plasma membrane, but it also plays various physiological functions including membrane trafficking, actin cytoskeletal reorganization, endocytosis, exocytosis, and the regulation of ion channels and transporters. PI (4,5) P 2 also becomes a precursor of intracellular signal transduction. The in vivo physiology of phosphoinositide (PI) -metabolizing enzymes has been analyzed based on the study of gene knockout mice. This review summarizes the cellular and physiological functions of PI-metabolizing enzymes.
Authors: Makoto Fujii, Satomi Kita, Ichiro Horie, Yusuke Gotoh, Takahiro Iwamoto
Language: Japanese
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2152394417