Work

Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.

Year: 1990

Type: article

Abstract: Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+, Mg2(+)-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+, Mg2(+)-ATPase. Inositol 1,4,5-triphosphate [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+, -Mg2(+)-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.

Source: Cell Regulation

DOI: 10.1091/mbc.1.10.781

Authors: A Verma, C A Ross, D Verma, S Supattapone, S H Snyder

Institution: Johns Hopkins University

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of General Medical Sciences