Work

Escape of Candida from Caspofungin Inhibition at Concentrations above the MIC (Paradoxical Effect) Accomplished by Increased Cell Wall Chitin; Evidence for β-1,6-Glucan Synthesis Inhibition by Caspofungin

Year: 2006

Type: article

Abstract: Concentrations above the MIC of caspofungin allow growth of some Candida isolates. A strain demonstrating paradoxical growth was grown in the presence and absence of caspofungin, and the cell wall content was analyzed. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00563-06

Authors: David A. Stevens, Masayuki Ichinomiya, Yukako Koshi, Hiroyuki Horiuchi

Institutions: Santa Clara Valley Medical Center, Stanford University, The University of Tokyo

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2152485629

FWCI: 11.3

Cites: 15

Cited by: 193

Related to: 10