Work

Imaging Mouse Cancer Models In Vivo Using Reporter Transgenes

Year: 2013

Type: preprint

Abstract: Imaging mouse models of cancer with reporter transgenes has become a relatively common experimental approach in the laboratory, which allows noninvasive and longitudinal investigation of diverse aspects of tumor biology in vivo. Our goal here is to outline briefly the principles of the relevant imaging modalities, emphasizing particularly their strengths and weaknesses and what the researcher can expect in a practical sense from each of these techniques. Furthermore, we discuss how relatively subtle modifications in the way reporter transgene expression is regulated in the cell underpin the ability of reporter transgenes as a whole to provide readouts on such varied aspects of tumor biology in vivo.

Source: Cold Spring Harbor Protocols

DOI: 10.1101/pdb.top069864

Authors: Scott K. Lyons, P. Stephen Patrick, Kevin M. Brindle

Institution: Cancer Research UK

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Cancer Research UK