Work

Direct Analysis of Conjugate Metabolites of Methamphetamine, 3,4-Methylenedioxymethamphetamine, and Their Designer Drugs in Biological Fluids

Year: 2009

Type: article

Abstract: This review summarizes technical improvements in the forensic analysis for conjugate metabolites of methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA) and their designer drugs. The improvements include the establishments of liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) in combination with the pretreatment methods. The direct determination techniques for the conjugates proved to be effective in rapidly and accurately examining many biological specimens without annoying hydrolysis. The metabolism of MA and MDMA, with attention to the phase II metabolism of the major hydroxy metabolites, is also discussed based on concentration data in biological specimens obtained from drug abusers.

Source: Eisei kagaku

DOI: 10.1248/jhs.55.495

Authors: Noriaki Shima, Munehiro Katagi, Hitoshi Tsuchihashi

Institution: Osaka Prefectural Police Department

Language: English

Topic: Forensic Toxicology and Drug Analysis

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2152568026

FWCI: 1.811

Cites: 35

Cited by: 12

Related to: 20