Work

A Device for Dried Blood Microsampling in Quantitative Bioanalysis: Overcoming The Issues Associated Blood Hematocrit

Year: 2014

Type: article

Abstract: AIMS: A cross-laboratory experiment has been performed on a novel dried blood sampler in order to investigate whether it overcomes issues associated with blood volume and hematocrit (HCT) that are observed when taking a subpunch from dried blood spot samples. MATERIALS & METHODS: An average blood volume of 10.6 μl was absorbed by the samplers across the different HCTs investigated (20-65%). RESULTS: No notable change of volume absorbed was noted across the HCT range. Furthermore, the variation in blood sample volumes across six different laboratories was within acceptable limits. CONCLUSION: The novel volumetric absorptive microsampling device has the potential to deliver the advantages of dried blood spot sampling while overcoming some of the issues associated with the technology.

Source: Bioanalysis

DOI: 10.4155/bio.14.310

Authors: Neil Spooner, Philip Denniff, Luc Michielsen, Ronald De Vries, Qin C Ji, Mark E Arnold, Karen Woods, Eric J Woolf, Yang Xu, Valérie Boutet, Patricia Zane, Stuart Kushon, James B Rudge

Institutions: GlaxoSmithKline (United Kingdom), Janssen (Belgium), Bristol-Myers Squibb (United States), AstraZeneca (United Kingdom), Merck & Co., Inc., Rahway, NJ, USA (United States), Sanofi (France), Sanofi (United States)

Language: English

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W2152575430

FWCI: 7.816

Cites: 26

Cited by: 217

Related to: 10