Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the Pgc-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring. Diabetes 2014;63:1605−1611
Year: 2014
Type: letter
Abstract: With great interest, we read the excellent study by Laker et al. (1) in this issue of Diabetes . The authors showed that exercise in mice on a high-fat diet, corresponding to “an unhealthy maternal lifestyle” scenario, can counteract the negative effects of diet-induced obesity through a metabolic pathway in the offspring in mice. Specifically, Laker et al. provided evidence that voluntary wheel exercise spanning 6 weeks prior to and throughout pregnancy reduces DNA methylation of Pgc-1α in muscle but not …
Source: Diabetes
DOI: 10.2337/db14-0086
Authors: Jonathan Cedernaes, Christian Benedict
Institution: Uppsala University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2152619432