Work

Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Year: 1996

Type: article

Abstract: The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.40.7.1717

Authors: V L Kan, A Geber, J E Bennett

Institutions: United States Department of Veterans Affairs, Veterans Health Administration, Washington DC VA Medical Center

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2152820645

FWCI: 1.262

Cites: 26

Cited by: 25

Related to: 10