Work

Two Additional Components of the Accessory Sec System Mediating Export of the Streptococcus gordonii Platelet-Binding Protein GspB

Year: 2005

Type: article

Abstract: The gspB-secY2A2 locus of Streptococcus gordonii strain M99 encodes the platelet-binding glycoprotein GspB, along with proteins that mediate its glycosylation and export. We have identified two additional components of the accessory Sec system (Asp4 and Asp5) encoded just downstream of gtfB in the gspB-secY2A2 locus. These proteins are required for GspB export and for normal levels of platelet binding by M99. Asp4 and Asp5 may be functional homologues of SecE and SecG, respectively.

Source: Journal of Bacteriology

DOI: 10.1128/jb.187.11.3878-3883.2005

Authors: Daisuke Takamatsu, Barbara A. Bensing, Paul M. Sullam

Institutions: San Francisco VA Medical Center, University of California, San Francisco

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Veterans Affairs, American Heart Association, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Prophage-Encoded Binding of S. mitis to Human Platelets, Role of Streptococcal-Platelet Binding in Endocarditis